The Portfolio Armor Substack

The Portfolio Armor Substack

Trade Alert: Finding A Floor

Two Multibaggers trades as biotech catalysts meet a bruising market.

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Portfolio Armor
Oct 23, 2026
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Scientists and engineers working indoors on precision brain-treatment technology, with windows behind them.

A Different Kind Of Strength

Thursday’s momentum selloff hit the iShares MSCI USA Momentum Factor ETF (MTUM 0.00%↑) hard: it fell 3.7%. uniQure (QURE 0.00%↑) gained 1.9%, while ClearPoint Neuro (CLPT 0.00%↑) finished flat.

Both biotech stocks are also up for the week through Thursday’s close: uniQure by 6.1% and ClearPoint by 2.0%, compared with a 1.6% decline for the momentum ETF. Here’s that divergence, measured from last Friday’s close.

Closing-price changes from October 16th through October 22nd, 2026: QURE up 6.1%, CLPT up 2.0%, MTUM down 1.6%.
Price changes from October 16th through October 22nd, 2026. Source: Yahoo Finance; chart by Portfolio Armor.

The Therapy And Its Delivery

In The Biology Won on June 17th, we explained why an FDA shift helped both companies.

The Biology Won

Portfolio Armor
·
Jun 17
The Biology Won

The FDA Blinks

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uniQure’s AMT-130 is a gene therapy for Huntington’s disease. ClearPoint provides navigation and delivery technology used to administer it directly into the brain.

The regulatory opening mattered to the therapy’s developer and to the company helping deliver it. We returned to that relationship in the free section of Fundamentals Get A Vote on June 29th, when we discussed making explicit exceptions for biotech re-rating opportunities.

Making The Exception Explicit

ClearPoint still fails our strict technical entry gates. Its resilience alongside uniQure during this week’s momentum meltdown suggests both stocks may be finding a bottom here. That’s the reason we’re making an exception and adding a new bullish trade on ClearPoint today. Negative clinical news or renewed FDA pushback could still send both stocks lower.

Both of today’s ideas come from our Multibaggers, a subset of accounts on our Market Watchers X list with documented winners of 100% or more. The second trade adds a separate biotech catalyst. Full entries and exit plans are below.

New to our alerts? Our overview explains how the service works:

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Aug 22
Start Here

How We Stack Multiple Edges

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Today’s First Multibaggers Trade

Theme: Gene therapy progress drives delivery demand.

RSI: 32; Chartmill Technical Rating: 0; Setup Rating: 3; Fundamental Rating: 2.

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